California Cancer Reporting System Standards, Volume III

IF1162: Primary Site, N 2016 – Ed 7

OWNER

COC/NPCR

EDIT SETS

California Hospital Transmit

Eureka Admission Level

Eureka Tumor Level

FIELDS

Date of Diagnosis [NAACCR #390]

TNM Edition Number [NAACCR #1060]

Primary Site [NAACCR #400]

Histologic Type ICD-O-3 [NAACCR #522]

Behavior Code ICD-O-3 [NAACCR# 523]

Age at Diagnosis [NAACCR #230]

CS Site-Specific Factor 10 [NAACCR #2864]

CS Site-Specific Factor 25 [NAACCR #2879]

Grade [NAACCR #440]

TNM Clin M [NAACCR #960]

TNM Path M [NAACCR #900]

Sex [NAACCR #220]

Type of Reporting Source [NAACCR# 500]

TABLE

AC7G2016.DBF

NP7NCL16.DBF

NP7NPA16.DBF

MESSAGE

IF1162: TNM N code problem
IF1162: TNM Path N code is invalid for site/hist combination
IF1162: TNM Clin N code is invalid for site/hist combination
IF1162: TNM Clin N code should = “88” for site/hist combination
IF1162: TNM Path N code should = “88” for site/hist combination

specification

TNM Clin N and TNM Path N may be blank. If TNM Clin N is entered, it is edited by the criteria below. If TNM Path N is entered, it is edited by the criteria below.

This edit is skipped if any of the following conditions are true:

Year of Date of Diagnosis is less than 2016, blank (unknown), or invalid
Type of Reporting Source = 7 (Death Certificate Only)
Histologic Type ICD-O-3 is blank
Behavior Code ICD-O-3 = 0 (benign) or 1 (borderline)
TNM Edition Number is not = 07 and not = 88
TNM Clin N and TNM Path N are both empty

The allowable values:

Clinical N: (blank), cX, c0, c0A, c0B, c1, c1A, c1B, c1C, c2, c2A, c2B, c2C, c3, c3A, c3B, c3C, c4, 88
Path N: (blank), pX, c0, p0, p0I-, p0I+, p0M-, p0M+, p1MI, p0A, p0B, p1, p1A, p1B, p1C, p2, p2A, p2B, p2C, p3, p3A, p3B, p3C, p4, 88

This edit checks the subset of values that are valid for each of the site/histology groups that have a TNM N defined and checks for ‘88’ if the site/histology group does not have a TNM N defined.

The number next to each site group indicates the chapter in the AJCC Cancer Staging Manual, Edition 7. The sites for each chapter are listed along with the histologies for which N is defined. The edit will pass when the codes listed are entered in TNM Clin N with "c" prefix or in TNM Path N with "p" prefix; "cN0" will also pass when entered in TNM Path N, and where specified “88” will pass the edit without the prefix. Blanks will also pass the edit but are not specified. For those cases where there is a difference between the clinical and pathologic N codes, such as Merkel Cell, Melanoma of Skin, Breast, Melanoma Conjunctiva, the N codes are listed separately for the clin and path assessment.

For example:

TNM N:

Clin: X,0,1,2,2A,2B,3,3A,3B,3C

Path: X,0,0I-,0I+,0M-,0M+,1,1A,1B,1C,1MI,2,2A,2B,3,3A,3B,3C

Translates to allowable codes of:

Clin: (blank),cX,c0,c1,c2,c2A,c2B,c3,c3A,c3B,c3C

Path: (blank),pX,c0,p0, p0I-,p0I+,p0M-,p0M+,p1,p1A,p1B,p1C,p1MI,p2,p2A,p2B,p3,p3A,p3B,p3C

The sites/histologies for each group are listed in the EditWriter table AC7G2016.DBF, except as noted below where special logic in this edit is used to assign or reassign sites/histologies to a specified group number.

This edit differs from the SEER edit of the same name in that it excludes N NOS categories that are not included in AJCC 7th Edition (Melanoma of Conjunctiva cN0).

Lip and Oral Cavity

Sites:

C000-C006,C008,C009

C020-C023,C028,C029

C030,C031,C039

C040,C041,C048,C049

C050,C058,C059

C060-C062,C068,C069

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,2A,2B,2C,3

Pharynx

Oropharynx and Hypopharynx Sites:

C019, C024

C051-C052

C090-C091, C098-C099

C100, C102-C104, C108-C109

C129

C130-C132, C138-C139

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,2A,2B,2C,3

Nasopharynx

Sites:

C110, C112-C113, C118-C119

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3,3A,3B

Nasopharynx

Sites:

C111

Discriminator (CS Site-Specific Factor 25):

010

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3,3A,3B

Oropharynx - Pharyngeal Tonsil

Sites:

C111

Discriminator (CS Site-Specific Factor 25):

010

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

Sites/histologies are assigned to group 4D from 4C based on Site-Specific Factor 25

TNM N:

X,0,1,2,2A,2B,2C,3

Larnyx

Supraglottis, Subglottis, Other

Sites:

C101, C321-C322

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,2A,2B,2C,3

Glottis

Sites:

C320, C328-C329

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980, 8981

TNM N:

X,0,1,2,2A,2B,2C,3

NOTE: TNM N 88 allowed for C328-C329

Nasal Cavity and Paranasal Sinuses

Sites:

C300, C310-C311

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,2A,2B,2C,3

Major Salivary Glands

Sites:

C079

C080,C081,C088,C089

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8982

TNM N:

X,0,1,2,2A,2B,2C,3, 88

Thyroid Gland

Thyroid: Papillary/follicular, age less than 045

Sites:

C739

Histologies Requiring AJCC Staging:

8000-8015, 8022, 8033-8344, 8350-8420, 8440-8508,

8514-8576, 8940-8950, 8980-8981

Age at Diagnosis: less than 045

Grade: 1-3 or 9

Site/histologies are assigned to group 8A from group 8 based on grade, age at diagnosis

TNM N:

X,0,1,1A,1B, 88

Thyroid: Papillary/follicular, age greater than or equal 045 but not 999

Sites:

C739

Histologies Requiring AJCC Staging:

8000-8015, 8022, 8033-8344, 8350-8420, 8440-8508,

8514-8576, 8940-8950, 8980-8981

Age at Diagnosis: greater than or equal to 045, but not equal 999

Grade: 1-3 or 9

Site/histologies are assigned to group 8B from group 8 based on grade, age at diagnosis

TNM N:

X,0,1,1A,1B, 88

Thyroid: Papillary/follicular, age equal 999 (unknown)

ites:

C739

Histologies Requiring AJCC Staging:

8000-8015, 8022, 8033-8344, 8350-8420, 8440-8508,

8514-8576, 8940-8950, 8980-8981

Age at Diagnosis: equal 999

Grade: 1-3 or 9

Site/histologies are assigned to group 8C from group 8 based on grade, age at diagnosis

TNM N:

X,0,1,1A,1B, 88

Thyroid: Medullary

Sites:

C739

Histologies Requiring AJCC Staging:

8345-8347, 8430, 8510, 8512-8513

Grade: 1-3 or 9

TNM N:

X,0,1,1A,1B, 88

Thyroid: Anaplastic

Sites:

C739

Histologies Requiring AJCC Staging:

8020-8021, 8030-8032

TNM N:

X,0,1,1A,1B

Thyroid: Anaplastic

Sites:

C739

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

Grade: 4

Site/histologies are assigned to group 8F from group 8 and group 8D based on grade

TNM N:

X,0,1,1A,1B

Mucosal Melanoma of the Head and Neck

Sites:

C000-C006, C008-C009

C019

C020-C024, C028-C029

C030-C031, C039

C040-C041, C048-C049

C050-C052, C058-C059

C060-C062, C068-C069

C090-C091, C098-C099

C100-C104, C108-C109

C110-C113, C118-C119

C129, C130-C132

C138-C139

C140, C142, C148

C300

C310-C311

C320-C323, C328-C329

Histologies Requiring AJCC Staging:

8720-8790

TNM N:

X,0,1, 88

Esophagus and Esophagus Gastric Junction

Esophagus

Sites:

C150-C155, C158-C159

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Esophagus Gastric Junction

Sites:

C160-C162

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8247-8248, 8250-8576, 8940-8950, 8980-8981

Discriminator (CS Site-Specific Factor 25):

020, 040, 060 (for C161-C162)

Site/histologies are assigned to group 10B from group 11 based on site and site-specific factor 25 as well as table lookup

TNM N:

X,0,1,2,3

Stomach

Sites:

C161-C162 and Discriminator (CS Site-Specific Factor 25) =

000, 030, 999

C163-C166, C168-C169

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8247-8248, 8250-8576, 8940-8950, 8980-8990

TNM N:

X,0,1,2,3,3A,3B

Small Intestine

Sites:

C170-C172, C178-C179

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8247-8248, 8250-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2

Appendix

Appendix: Carcinoma

Sites:

C181

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8247-8248, 8250-8576, 8940-8950, 8980-8981

TNM N:

0,1,1A,1B

Appendix: Carcinoid

Sites:

C181

Histologies Requiring AJCC Staging:

8240-8242, 8246, 8249, 8153

TNM N:

X,0,1, 88

Colon and Rectum

Sites:

C180, C182-C189

C199

C209

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8247-8248, 8250-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,1A,1B,1C,2,2A,2B

Anus

Sites:

C210-C212, C218

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8250-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Gatrointestinal Stromal Tumor (GIST)

GIST: Gastric

Sites:

C160-C169

C480-C488 and CS Site-Specific Factor 10 = 020 (Omentum)

Histologies Requiring AJCC Staging:

8935-8936

Sites/histologies are assigned to group 16A from group 16B based on site-specific factor 10 as well as table lookup

TNM N:

0,1, 88

GIST: Small Intestine

Sites:

C150-C159

C170-C172, C178, C179

C180-C189

C199

C209

C480-C488 and CS Site-Specific Factor 10 not = 020 (Omentum)

Histologies Requiring AJCC Staging:

8935-8936

TNM N:

0, 1, 88

Neuroendocrine Tumors (NET)

NET: Stomach

Sites:

C160-C169

Histologies Requiring AJCC Staging:

8153, 8240-8242, 8246, 8249

TNM N:

X,0,1

NET: Small Intestine and Ampulla of Vater

Sites:

C170-C179

C241

Histologies Requiring AJCC Staging:

8153, 8240-8242, 8246, 8249

TNM N:

X,0,1, 88

NET: Colon and Rectum

Sites:

C180, C182-C189

C199, C209

Histologies Requiring AJCC Staging:

8153, 8240-8242, 8246, 8249

TNM N:

0,1, 88

Liver

Sites:

C220

Histologies Requiring AJCC Staging:

8170-8175

TNM N:

X,0,1, 88

Intrahepatic Bile Ducts

Sites:

C221

Histologies Requiring AJCC Staging:

8160, 8161, 8180

TNM N:

X,0,1

Gallbladder

Sites:

C239

C240 and Discriminator (CS Site-Specific Factor 25) = 030

Histologies Requiring AJCC Staging:

8000-8152,8154-8231, 8243-8245, 8250-8576, 8940-8950, 8980-8981

Sites/histologies are assigned to group 20 from group 21 based on site-specific factor 25

as well as table lookup

TNM N:

X,0,1,2

Perihilar Bile Ducts

Sites:

C240 and Discriminator (CS Site-Specific Factor 25) = 010, 020, 050, 060, 999

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8250-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2

Distal Bile Duct

Sites:

C240 and Discriminator (CS Site-Specific Factor 25) = 040, 070

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8250-8576, 8940-8950, 8980-8981

Sites/histologies are assigned to group 22 from group 21 based on site-specific factor 25 as well as table lookup

TNM N:

X,0,1

Ampulla of Vater

Sites:

C241

Histologies Requiring AJCC Staging:

8000-8152, 8154-8231, 8243-8245, 8250-8576, 8940-8950, 8980-8981

TNM N:

X,0,1

Exocrine and Endocrine Pancreas

Sites:

C250-C254, C257-C259

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8971, 8980-8981

TNM N:

X,0,1

Lung

Sites:

C340-C343,C348,C349

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Pleural Mesothelioma

Sites:

C384

Histologies Requiring AJCC Staging:

9050-9053

TNM N:

X,0,1,2,3

Bone

Sites:

C400-C403, C408-C409

C410-C414, C418-C419

Histologies Requiring AJCC Staging:

8800-9136, 9142-9582

TNM N:

X,0,1

Soft Tissue Sarcoma

Peritoneum - not female

Sites:

C481-C482, C488

Histologies Requiring AJCC Staging:

8800-8820, 8823-8934, 8940-9136, 9142-9582

Sex is 1, 3-5, 9 (not female)

Peritoneum - female

Sites:

C481-C482, C488

Histologies Requiring AJCC Staging:

8800-8820, 8823-8935, 8940-9136, 9142-9582

Sex is 2, 6 (female)

Heart,Mediastinum, Soft Tissue

Sites:

C380-C383, C388

C470-C476, C478-C479

C490-C496, C498-C499

Histologies Requiring AJCC Staging:

8800-8820, 8823-8935, 8940-9136, 9142-9582

Retroperitoneum

Sites:

C480

Histologies:

8800-8820, 8823-8934, 8940-9136, 9142-9582

Specific sites/histologies assigned to group 28 based on sex

TNM N:

X,0,1

NOTE: TNM N 88 allowed for Mesothelioma, 9050-9055

Cutaneous Squamous Cell Carcinoma and other Cutaneous Carcinomas

Sites:

C440, C442-C449, C632

Histologies Requiring AJCC Staging:

8000-8246, 8248-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,2A,2B,2C,3

Merkel Cell Carcinoma

Sites:

C440, C442-C449,

C510-C512, C518-C519

C600-C602, C608-C609

C632

Histologies Requiring AJCC Staging:

8247

TNM N:

Clin: X,0,1,2

Path: X,0,1,1A,1B,2

Melanoma of the Skin

Sites:

C440-C449

C510-C512,C518,C519

C600-C602, C608, C609

C632

Histologies Requiring AJCC Staging:

8720-8790

TNM N:

Clin: X,0,1,1A,1B,2,2C,3

Path: X,0,1,1A,1B,2,2A,2B,2C,3

Breast

Sites:

C500-C506,C508,C509

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981, 9020

TNM N:

Clin: X,0,1,2,2A,2B,3,3A,3B,3C

Path: X,0,0I-,0I+,0M-,0M+,1,1A,1B,1C,1MI,2,2A,2B,3,3A,3B,3C

Vulva

Sites:

C510-C512,C518,C519

Histologies Requiring AJCC Staging:

8000-8246, 8248-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,1A,1B,2,2A,2B,2C,3

Vagina

Sites:

C529

Histologies Requiring AJCC Staging:

8000-8576, 8800-8801, 8940-8950, 8980-8981

TNM N:

X,0,1

Cervix Uteri

Sites:

C530,C531,C538,C539

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1

Corpus Uteri

Corpus Uteri: Carcinomas

Sites:

C540-C543, C548-C549

C559

Histologies Requiring AJCC Staging:

8000-8790, 8950-8951, 8980-8981

TNM N:

X,0,1,2

Corpus Uteri: Leiomyosarcoma and Endometrial Stromal Sarcoma

Sites:

C540-C543, C548-C549

C559

Histologies Requiring AJCC Staging:

8800, 8890-8898, 8900-8921, 8930-8931, 8935

TNM N:

X,0,1,2

Corpus Uteri: Adenosarcoma

Sites:

C540-C543, C548-C549

C559

Histologies Requiring AJCC Staging:

8933

TNM N:

X,0,1,2

Ovary and Peritoneal Carcinomas

Ovary

Sites:

C569

Histologies Requiring AJCC Staging:

8000-8576, 8590-8671, 8930-9110

TNM N:

X,0,1, 88

Peritoneal Carcinomas

Sites:

C481-C482, C488

Sex = 2,6 (female)

Histologies Requiring AJCC Staging:

8000-8576, 8590-8671, 8930-8934, 8940-9110

TNM N:

X,0,1

Fallopian Tube

Sites:

C570

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1

Gestational Trophoblastic Tumors

Sites:

C589

Histologies Requiring AJCC Staging:

9100-9105

TNM N:

Penis

Sites:

C600-C602,C608,C609

Histologies Requiring AJCC Staging:

8000-8246, 8248-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Prostate

Sites:

C619

Histologies Requiring AJCC Staging:

8000-8110, 8140-8576, 8940-8950, 8980-8981

TNM N:

X,0,1, 88

Testis

Sites:

C620,C621,C629

Histologies Requiring AJCC Staging:

8000-8576, 8590-8670, 8940-8950, 8980-8981, 9060-9090, 9100-9105

TNM N:

X,0,1,2,3

Kidney

Sites:

C649

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1, 88

Renal Pelvis and Ureter

Sites:

C659

C669

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Urinary Bladder

Sites:

C670-C679

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2,3

Urethra

Sites:

C680

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,2

Adrenal

Adrenal Cortex

Sites:

C740

Histologies Requiring AJCC Staging:

8010, 8140, 8370

TNM N:

X,0,1, 88

Adrenal Cortical Carcinoma

Sites:

C749

Histologies Requiring AJCC Staging:

8370

TNM N:

X,0,1, 88

Carcinoma of the Eyelid

Sites:

C441

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1

Conjunctiva

Sites:

C690

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1

Malignant Melanoma of the Conjunctiva

Sites:

C690

Histologies Requiring AJCC Staging:

8720-8790

TNM N:

Clin: X,0A,0B,1

Path: X,0,0A,0B,1

Malignant Melanoma of Uvea

Ciliary Body and Choroid

Sites:

C693

C694 (CS Site-Specific Factor 25 = 010)

Histologies Requiring AJCC Staging:

8720-8790

Sites/histologies are assigned to group 51A from group 51 based on site-specific factor 25

TNM N:

X,0,1,88

Iris

Sites:

C694 (CS Site-Specific Factor 25 = 020)

Histologies Requiring AJCC Staging:

8720-8790

Sites/histologies are assigned to group 51B from group 51 based on site-specific factor 25

TNM N:

X,0,1,88

Retinoblastoma

Sites:

C692

Histologies Requiring AJCC Staging:

9510-9514

TNM N:

X,0,1,2

Carcinoma of the Lacrimal Gland

Sites:

C695 and CS Site-Specific Factor25 = 015

Histologies Requiring AJCC Staging:

8000-8576, 8940-8950, 8980-8981

TNM N:

X,0,1,88

Sarcoma of the Orbit

Sites:

C696, C698

Histologies Requiring AJCC Staging:

8800-8936, 8940-9136, 9141-9508, 9520-9582

TNM N:

X,0,1, 88

Ocular Adnexal Lymphoma

Sites:

C441, C690, C695-C696

Histologies Requiring AJCC Staging:

9590-9699, 9702-9738, 9811-9818, 9820-9837

TNM N:

X,0,1,2,3,4

Brain and Spinal Cord

Sites:

C700, C701, C709, C710-C719, C720-C729, C751-C753

Histologies Requiring AJCC Staging:

8000, 8680-9136,9141-9582

TNM N:

Lymphoid Neoplasms

Hodgkin and Non-Hodgkin

Sites:

C000-C440, C442-C689, C691-C694, C698-C809

Histologies Requiring AJCC Staging:

9590-9699, 9702-9727, 9735, 9737-9738

Sites:

C000-C419, C422-C423, C425-C440, C442-C689, C691-C694, C698-C809

Histologies Requiring AJCC Staging:

9811-9818, 9823, 9827, 9837

Sites/histologies are assigned to group 57A based on combinations of site and histology

TNM N:

Primary Cutaneous Lymphomas

Sites:

C440-C449

C510-C512, C518-C519

C600-C602, C608-C609, C632

Histologies Requiring AJCC Staging:

9700, 9701

TNM N:

X,0,1,1A,1B,2,2A,2B,3,88

Lymphoid/Hematopoietic

Sites:

C420, C421, C424

Histologies Requiring AJCC Staging:

9811-9818, 9837

TNM N:

All Others

TNM N:

historical changes

08/2016	Per NAACCR v16, new edit added.
09/2016	Per NAACCR v16A: Corrected logic for first INLIST of primary sites for site/histology group 57A, 000-419-440 changed to 000-440 Updated description to indicate 0A and 0B allowable values for TNM Pathologic N for site/histology group 050, Melanoma of Conjunctiva. Table referenced by logic updated to include these codes Corrected Description and Edit Logic to include 9727 as lymphoma rather than lymphoma/hematopoietic code, to delete 9728-9729 as obsolete codes Added Group 57C, C420, C421, C424, 9811-9818, 9837, TNM N 88
11/2016	Per NAACCR v16B, corrected edit logic for assigning site/histology group 011 to group 10B or 999 based on histology and CS Site-Specific Factor 25.
03/2017	Per NAACCR v16D: Description, logic updated to allow clinical and pathologic TNM N 88 for mesothelioma, 9050-9055, site/histo group 028. Removed substring variable declarations from logic, not used. Description, logic updated to allow clinical and pathologic TNM M 88 for C32.8 and C32.9, site/histo group 05B.