IF1166: Inconsistency between TNM categories T [value] N [value] M [value] and assigned TNM stage [value]
IF1166: Combination of T [value] N [value] M [value] is invalid for TNM staging
IF1166: T [value] N [value] M [value], staging parameter for [value], inconsistent with TNM stage [value]
IF1166: Combination T [value] N [value] M [value], staging parameter for [value], invalid for TNM staging

specification

This edit is skipped if any of the following conditions are true:

Year of Date of Diagnosis is less than 2016, blank (unknown), or invalid
Type of Reporting Source = 7 (Death Certificate Only)
Histologic Type ICD-O-3 is blank
Behavior Code ICD-O-3 = 0 (benign) or 1 (borderline
TNM Edition Number is not = 07, U7, 88
TNM Clin Stage Group is blank
TNM Clin T or TNM Clin M is blank

The purpose of this edit is to validate the coded TNM categories, and site-specific staging parameters where used, with the coded Stage Group assignments. The edit is used for site/histology groups in AJCC 7th Edition chapters 29 through 57. Some TNM chapters require elements in addition to T, N, and M categories, such as grade or mitotic rate. for correct stage assignment. In this edit description, these elements are called staging parameters. The edit will not be skipped but will pass if any of TNM Clin N or a required staging parameter is blank. (The exception for TNM Clin N allows for the possible coding of TNM Clin N as blank for site/histology group 39; if blank, TNM Clin N will be converted to "88" for the edit.)

The edit compares the combination of TNM Clin T, TNM Clin N, TNM Clin M categories, and staging parameter where required, with TNM Clin Stage Group.

The designation of "c" or "p" within the individual T, N, and M codes is ignored for this edit. Valid codes for individual fields (TNM Clin T, TNM Clin N, TNM Clin M, TNM Clin Stage Group), and for these individual fields by primary site, are checked in other edits.

An edit failure is returned if the Clin Stage Group is inconsistent with the expected group assignment for the coded T, N, M, and staging parameter if required, based on the AJCC stage tables. If a T, N, or M value is coded that is not included in the AJCC stage tables -- for example T4 is coded but only T4A and T4B are staged -- the stage assignment will not be checked and the edit will pass.

An edit failure is also returned if either the coded Clin Stage Group or the coded Path Stage Group returns "ERROR" from the lookup table, meaning that the combination of T, N, M, and staging parameter is invalid. Invalid combinations include T0N0M0/M0I+; T in situ with positive N and/or positive M category; and a Testis stage with an invalid S category. An invalid S category results when one or more of the 3 site-specific factors required to determine the category (SSF 13-AFP, SSF 15-hCG, SSF 16-LDH) is coded 988, meaning not applicable.

The site/histology groups are listed below. The number next to each site title indicates the respective chapter in the AJCC Cancer Staging Manual, Edition 7.The site/histology groups and group stage values are identified by site and histology in the edit Primary Site, Stage Group 2016 - Ed 7. Subdivisions of some groups were required for this edit; they are identified below with their criteria. Site-specific staging parameters are also identified. The description does not include the list of TNM categories, staging parameters, and stage groups; this information is contained in a table within EditWriter that contains around 14,000 records.

Site/histology groups 49, Carcinoma of Conjunctiva, 50, Malignant Melanoma of Conjunctiva, 52, Retinoblastoma, 53, Carcinoma of Lacrimal Gland, 54, Sarcoma of Orbit, 55, Ocular Adnexal Lymphoma, are listed below. However, staging for these site/histology groups is not validated by this edit, as no stage grouping applies. The T, N, M codes for site/histology groups 49, 50, 52, 53, 54, and 55 are validated in the edits Primary Site, T 2016 - Ed 7, Primary Site, N 2016 - Ed 7, and Primary Site, M 2016 - Ed 7.

Site/histology group 57A, Lymphoid Neoplasms, is also listed below. However, staging for 57A does not include T, N, and M components, and stage is not validated in this edit. The T, N, M codes for site/histology group 57A are validated in the edits Primary Site, T 2016 - Ed 7, Primary Site, N 2016 - Ed 7, and Primary Site, M 2016 - Ed 7. Stage group for 57A is validated in the edit Primary Site, Stage Group 2016 - Ed 7. Site/histology group 55, Ocular Adnexal Lymphoma, will pass this edit if coded as Lymphoma (T=88,N=88,M=88,Stage Group = stage from Ch 57), or as Ocular Adnexal Lymphoma (T=T from Ch 55, N=N from Ch 55, M=M from Ch 55, Stage Group = 88).

Cutaneous Squamous Cell Carcinoma and other Cutaneous Carcinomas
Merkel Cell Carcinoma
Melanoma of the Skin
Breast
Vulva
Vagina
Cervix Uteri
Corpus Uteri

36 A. Corpus Uteri: Carcinomas

36 B. Corpus Uteri: Leiomyosarcoma and Endometrial Stromal Sarcoma

36 C. Corpus Uteri: Adenosarcoma

Ovary and Peritoneal Carcinomas

37A. Ovary

37B. Peritoneal Carcinomas

Fallopian Tube

Gestational Trophoblastic Tumors

Staging Parameter: Prognostic Scoring Index as collected in CS SSF 1

Penis
Prostate

Division for Staging:

41A. PSA: 988, 997, 998, 999

41B. PSA: 001-099

41C. PSA: 100-199

41D. PSA: 200-980

Staging Parameter: Gleason Score: As collected in CS SSF 8 for clinical stage

Testis

Staging Parameter: S value, based on calculation of:

post-orchiectomy AFP value as collected in CS SSF 13,

post-orchiectomy hCG value as collected in CS SSF 15,

post-orchiectomy LDH range as collected in CS SSF 16

Kidney
Renal Pelvis and Ureter
Urinary Bladder
Urethra
Adrenal

47A. Adrenal Cortex

47B. Adrenal Cortical Carcinoma

Carcinoma of the Eyelid
Conjunctiva
Malignant Melanoma of the Conjunctiva
Malignant Melanoma of Uvea

51A. Ciliary Body and Choroid

51B. Iris

Retinoblastoma

Carcinoma of the Lacrimal Gland
Sarcoma of the Orbit
Ocular Adnexal Lymphoma

Lymphoid Neoplasms

57A. Hodgkin and Non-Hodgkin Lymphoma

57B. Primary Cutaneous Lymphomas

Staging Parameter: Peripheral blood involvement, as collected in CS SSF 1

historical changes

08/2016	Per NAACCR v16, new edit added.
09/2016	Per NAACCR v16A: Added stage mapping to table referenced by logic for T1A, T1B, T2A, T2B to site/group 57B, Primary Cutaneous Lymphoma Corrected site group in edit logic, 41E to 41A, defined for Prostate where CS Site-Specific Factor 1 = 988, 997, 998, 999 Corrected Edit Logic to include 9727 as lymphoma rather than lymphoma/leukemia code, to delete 9728-9729 as obsolete codes Added Group 57C, C420, C421, C424, 9811-9818, 9837 to Edit Logic
11/2016	Per NAACCR v16B: Removed logic checking for Over-ride Site/TNM-StgGrp. This Over-ride allows pediatric cases to be coded with stage group 88. The stage tables do not look for combinations of 88 88 88 88, so any record with such a combination would not be edited with the edit. An edit failure based on incorrect setting of the Over-ride would duplicate the same edit failure in an edit that checks primary site, stage group values for 2016. Table referenced by edit updated: TA,NX,M0, stage group changed to ERROR from 0A; TISD,NX,M0,stage group changed to ERROR from 0IS; TISU,NX,M0, stage group changed to ERROR from 0IS; TIS,NX,M0, stage group changed to ERROR from 0. Table referenced by logic updated, stage groups for 042 limited to cases with category TIS or TX with SX. Corrected edit logic for assigning site/histology group 011 to group 10B or 999 based on histology and CS Site-Specific Factor 25.
03/2017	Per NAACCR v16D: Added U7 to required TNM Edition Numbers. Staging table referenced by edit updated for site/histology groups 032 (Breast), 51A (Uveal Melanoma), and 57B (Primary Cutaneous Lymphoma), values for NOS stage groups not listed in AJCC 7th Edition changed to 99 (e.g., 032, T4NXM0, Stage group 3, changed to T4NXM0, Stage group 99). Table referenced by edit updated, 57B, rows for T1A,T1B,T2A,T2B, M0 added.